The purposes of this investigation were to examine the effects of anabolic steroid treatment on protein synthesis in skeletal muscle and on steroid receptors. The experiments were conducted with 230 male albino rats maintained on a diet containing 20% protein. Anabolic steroids (methandrostenolone, methylandrostendiole, and Retabolil) were injected in doses of mg/kg body weight. The animals were examined at rest and after swimming exercise of 15 min duration. Quadriceps and gastrocnemius muscle were used for analysis in all experiments. Protein synthesis was studied by means of 14C-leucine incorporation. It was found that anabolic steroid treatment resulted in an increased content of skeletal muscle protein: myosin, myofibrillar, and sarcoplasmic fractions. The activity of RNA-polymerase in skeletal muscle nuclei was increased. The results indicated that in skeletal muscle there were androgen receptors which were binding sites for 3H-testosterone and anabolic steroids. A model for the anabolic steroid action on the regulation of protein synthesis in skeletal muscle was proposed.
I totally understand what kind of job you had. I work at a Wally World distribution center. Started in shipping, loading about 3 to 4 full semi’s a day. Didn’t know how much weight I loaded. Then switched to non conveyable. When in dog food, I’d stack about 60k/lbs in 12 hours. That was MUCH easier than shipping. My first year, I struggled. Then I talked to my bro-in-law, who is a personal trainer, found and I started to do good. I was taking creatine and C4 prior to work, and took an Animal Pak with UniLiver every break, while eating protien every 3-4 hours. This brought me to Muscle for Life and The Books. I’m in maintenance department now, and are about to join a gym. I’ve been wanting to get the Legion multi’s and switch to Legion supplements. I’m about done reading BLS, and are gonna start the year one challenge. I’ve aready bought BBLS and Shredded Chef. I get excited every time I think about my goals.
The use of anabolic steroids such as Winstrol may be associated with serious adverse reactions, many of which are dose related. Patients should be placed on the lowest possible effective dose. Medications that may interact with Winstrol include anticoagulants (blood thinners), insulin , or an oral diabetes medicine. Tell your doctor all medications you are taking. Winstrol is known to cause birth defects in a fetus. Do not take this medication if you are pregnant or could become pregnant during treatment. It is not known whether Winstrol is excreted in human milk. Many drugs are excreted in human milk and there is the potential for adverse reactions in nursing infants from anabolic steroids. Consult your doctor before breastfeeding.