We anticipated that outcomes would be reported after different durations of treatment, and extracted data reported as close to seven days as possible, with a minimum of three days. Where outcomes were reported after longer durations of treatment these would also be extracted. We also anticipated that reporting of adverse events would vary between studies with regard to the terminology used, method of ascertainment, and categories reported (. occurring in at least 5% of participants or where there is a statistically significant difference between treatment groups). Care was taken to identify these details where relevant.