In a sham-controlled, randomized, double-blinded study, Bradley et al (2002) evaluated the effectiveness of tidal irrigation (TI) in comparison with a well-matched sham irrigation (SI) procedure as a treatment for OA of the knee. A total of 180 patients with knee OA were randomized to receive TI or SI, with clinical follow-up over the ensuing 12 months. The primary outcomes of interest were changes in pain and function, as measured by the WOMAC. Patients and the nurse assessor were blinded, and success of blinding was assessed. Although the study groups were otherwise comparable, the baseline WOMAC pain and physical functioning scores were higher (worse) in the SI group. After adjustment for baseline, there were no differences between the effects of SI and TI. Blinding was successful with approximately 90 % of SI and TI patients stating that they had received the TI procedure. The authors concluded that the improvement of these patients with knee OA following TI was due to a placebo effect.
Results Among 140 randomized patients (mean age, 58 [SD, 8] years, 75 women [54%]), 119 (85%) completed the study. Intra-articular triamcinolone resulted in significantly greater cartilage volume loss than did saline for a mean change in index compartment cartilage thickness of − mm vs − mm (between-group difference, − mm; 95% CI, − to − mm); and no significant difference in pain (− vs −; between-group difference, −; 95% CI, − to ). The saline group had 3 treatment-related adverse events compared with 5 in the triamcinolone group and had a small increase in hemoglobin A 1c levels (between-group difference, −%; 95% CI, −% to −%).
SUPARTZ is indicated for treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, ., acetaminophen. You should not use SUPARTZ if you have infections or skin diseases at the injection site or allergies to poultry products. SUPARTZ is not approved for pregnant or nursing women, or children. Risks can include general knee pain, warmth and redness or pain at the injection site. Full prescribing information can be found here or by contacting customer service at 800-396-4325.