Beclometasone dipropionate was first patented in 1962 and used medically in 1972.  It was approved for medical use in the United States in 1976.  It is on the World Health Organization's List of Essential Medicines , the most effective and safe medicines needed in a health system .  The wholesale price in the developing world for an inhaler containing 200 doses of medication is about USD as of 2014.  In the United States it costs between 50 and 100 USD for a typical month supply of the inhaled form. 
Mometasone furoate increased chromosomal aberrations in an in vitro Chinese hamster ovary-cell assay, but did not increase chromosomal aberrations in an in vitro Chinese hamster lung cell assay. Mometasone furoate was not mutagenic in the Ames test or mouse- lymphoma assay, and was not clastogenic in an in vivo mouse micronucleus assay and a rat bone marrow chromosomal aberration assay or a mouse male germ -cell chromosomal aberration assay. Mometasone furoate also did not induce unscheduled DNA synthesis in vivo in rat hepatocytes.