The ability to promote gains in both muscle and fat makes these drugs unique among the medications used for HIV wasting disease, notes Grunfeld. He says that among patients with serious wasting illnesses, the benefits of immediate weight gain could still potentially outweigh the risks of longer-term heart and liver damage. For these patients, he says, it is important to have a store of fat as well as muscle mass, because “opportunistic infections burn up muscle if there’s no fat there. The more fat you have, the less muscle you burn.”
Follow-up was completed in all resuscitated patients. Patients in the VSE group vs patients in the control group had higher probability for ROSC of 20 minutes or longer (109/130 [%] vs 91/138 [%]; odds ratio [OR], ; 95% CI, -; P = .005) and survival to hospital discharge with CPC score of 1 or 2 (18/130 [%] vs 7/138 [%]; OR, ; 95% CI, -; P = .02). Patients in the VSE group with postresuscitation shock vs corresponding patients in the control group had higher probability for survival to hospital discharge with CPC scores of 1 or 2 (16/76 [%] vs 6/73 [%]; OR, ; 95% CI, -; P = .02), improved hemodynamics and central venous oxygen saturation, and less organ dysfunction. Adverse event rates were similar in the 2 groups.
Usually you won’t have a problem with a high dose for five days if given as a burst to treat a medical problem.
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