Q. Is alcoholism very much related to cirrhosis? I have heard that people who drink a lot get cirrhosis….is alcoholism very much related to cirrhosis? A. HELLO ROHAN,YES alcoholism is related to CIRRHOSIS OF THE cancer developes in about one in five sufferers of alcohol consumption increases the risk of cancers of the mouth,tongue,pharynx(back of the throat),larynx(voice box),and esophagus,---liver disease caused by a high alcohol consumption include (fatty liver)-(alcoholic hepatitis)(cirrhosis)and liver causes nervous system disorders,(confusion)(disturbance of speech)(weakness in the legs)(psychosis).the heart is affected by reducing pumping efficiency,usually combined with edema(fluid collection in the tissues.---mrfoot56
The classic histologic features of alcoholic hepatitis include inflammation and necrosis, which are most prominent in the centrilobular region of the hepatic acinus ( Figure 2 ). Hepatocytes are classically ballooned, which causes compression of the sinusoid and reversible portal hypertension. The inflammatory cell infiltrate, located primarily in the sinusoids and close to necrotic hepatocytes, consists of polymorphonuclear cells and mononuclear cells. In addition to inflammation and necrosis, many patients with alcoholic hepatitis have fatty infiltration and Mallory bodies, which are intracellular perinuclear aggregations of intermediate filaments that are eosinophilic on hematoxylin-eosin staining. Neither fatty infiltration nor Mallory bodies are specific for alcoholic hepatitis or necessary for the diagnosis. 16
Treatment: If a pancreatic or liver tumor is identified and able to be surgically excised, the skin lesions may normalize for an extended period of time, but because these tumors metastasize (spread to other areas of the body) quickly, surgery is not curative. In cases of end stage liver disease, surgery is not possible, and the goal of therapy is to increase quality of life and decrease uncomfortable skin lesions with supportive care and addressing the nutritional abnormalities. Supportive care includes supplementing protein and necessary minerals and enzymes through the diet and oral supplements or by weekly intravenous amino acid infusions that are performed in the hospital on an outpatient basis until improvement in the skin is noted. Unfortunately, despite the supportive care, the disease will progress.