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Telmisartan has been used by endurance athletes as an alternative to the banned substances AICAR and GW1516. It is also a relatively safe and non-toxic drug used by athletes in dosages of 80-160 mg/day in divided dosages. The latter two drugs have been banned. Telmisartan has been shown to act by a similar mechanism. Specifically, telmisartan promises to enhance running ability, increase fat burning ability, reduce lactic acid formation and enhance recovery from exercise. However, its actual performance-enhancing effects remain the subject of debate.

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